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KMID : 1155520080030010044
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Anesthesia and Pain Medicine
2008 Volume.3 No. 1 p.44 ~ p.48
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Effects of Steroid Administration on the Blood Glucose Level during Spine Surgery in Patients with Metabolic Syndrome
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Kim Hyun-Jung
Kim Dong-Won
Kim Bum-Suk
Kim Kyu-Nam
Shim Jae-Chul
Suh Jung-Kook
Yi Hyeong-Joong
Ryu Keon-Hee
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Abstract
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Background: The risk of steroid-induced hyperglycemia is debated, and methylprednisolone is still used during spinal surgery.We have compared the blood glucose level in patients with metabolic syndrome treated with or without methylprednisolone.
Methods: This study was conducted in 68 adult patients who underwent elective spine surgery.Patients were classified into the following groups: methylprednisolone group (n = 39, group M), placebo group (n = 29, group P), group M patients with metabolic syndrome (n = 17, group MM), and group P patients without metabolic syndrome (n = 21, group NMP).Before and after injection of either 125 mg methylprednisolone or a placebo, we consecutively checked the blood glucose level every 30 minutes up to 4 hours.
Results: The blood glucose level was significantly increased in group M patients as compared to group P patients.The blood glucose level was more significantly increased in group MM as compared to group NMP patients.The increased blood glucose levels over 4 hours were 50 mg/dl in group MM and 35 mg/dl in group NMP patients.
Conclusions: We recommend that close monitoring of the blood glucose level up to several hours after injection of a steroid should be seriously considered during spine surgery, particularly in patients with metabolic syndrome.
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KEYWORD
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blood glucose, methylprednisolone, spine surgery
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